Application of the GA/KNN method to SELDI proteomics data

Bioinformatics. 2004 Jul 10;20(10):1638-40. doi: 10.1093/bioinformatics/bth098. Epub 2004 Feb 12.

Abstract

Summary: Proteomics technology has shown promise in identifying biomarkers for disease, toxicant exposure and stress. We show by example that the genetic algorithm/k-nearest neighbors method, developed for mining high-dimensional microarray gene expression data, is also capable of mining surface enhanced laser desorption/ionization-time-of-flight proteomics data.

Availability: The source code of the program and documentation on how to use it are freely available to non-commercial users at http://dir.niehs.nih.gov/dirbb/lifiles/softlic.htm

Publication types

  • Comparative Study
  • Evaluation Study
  • Validation Study

MeSH terms

  • Algorithms*
  • Biomarkers / blood*
  • Female
  • Gene Expression Profiling / methods
  • Humans
  • Neoplasm Proteins / blood*
  • Neoplasm Proteins / classification
  • Ovarian Neoplasms / blood*
  • Ovarian Neoplasms / diagnosis
  • Proteome / analysis*
  • Proteomics / methods*
  • Reference Values
  • Reproducibility of Results
  • Sensitivity and Specificity
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*

Substances

  • Biomarkers
  • Neoplasm Proteins
  • Proteome