Pulmonary hyalinizing granuloma with laryngeal and subcutaneous involvement: report of a case successfully treated with glucocorticoids

Intern Med. 2004 Jan;43(1):69-73. doi: 10.2169/internalmedicine.43.69.

Abstract

We report a case of pulmonary hyalinizing granuloma (PHG) with laryngeal and subcutaneous involvement. A 43-year-old man was admitted to our hospital for assessment of hoarseness. Cervical and chest computed tomography, respectively, revealed a laryngeal tumor and two pulmonary masses. Specimens obtained from the pulmonary masses were compatible with PHG. The histopathology of biopsy specimens from both the laryngeal tumor and a subcutaneous tumor resembled that of the resected lung masses. Although there is no established treatment for PHG, the laryngeal tumor was diminished and all other lesions disappeared with glucocorticoid treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy, Needle
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Follow-Up Studies
  • Glucocorticoids / administration & dosage*
  • Granuloma, Laryngeal / complications
  • Granuloma, Laryngeal / diagnosis
  • Granuloma, Laryngeal / drug therapy
  • Granuloma, Respiratory Tract / complications
  • Granuloma, Respiratory Tract / diagnosis*
  • Granuloma, Respiratory Tract / drug therapy*
  • Humans
  • Immunohistochemistry
  • Lung Diseases / complications
  • Lung Diseases / diagnosis
  • Lung Diseases / drug therapy*
  • Male
  • Radiography, Thoracic
  • Radionuclide Imaging / methods
  • Skin Diseases / complications
  • Skin Diseases / diagnosis
  • Skin Diseases / drug therapy*
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Glucocorticoids