This report describes a non-Hodgkin lyphoma case presenting with skeletal muscle and cutaneous involvement. A 75 year-old man was admitted to hospital with mass in the right upper extremity and skin lesions on the back of his trunk. Excisional mass biopsy was reported immunohistopthologically as large B-cell lymphoma. Primary extranodal lymphoma arising from skeletal muscle and concomitant skin infiltration of other body localization is not common. So this case was represented and relevant literature was reviewed.