Comparative study of action mechanisms of dimebon and memantine on AMPA- and NMDA-subtypes glutamate receptors in rat cerebral neurons

Bull Exp Biol Med. 2003 Nov;136(5):474-7. doi: 10.1023/b:bebm.0000017097.75818.14.

Abstract

Dimebon in low concentrations potentiated activity of AMPA-receptors in rat cerebellar Purkinje neurons, while memantine produced only an insignificant potentiation in a small group of these cells. In cortical neurons of rat brain memantine efficiently blocked NMDA-induced currents in dimebon-insensitive neurons. By contrast, its effect was far weaker in neurons, where the blocking action of dimebon on NMDA-receptors was most pronounced. It was hypothesized that the differences in the effects of memantine and dimebon are determined by their interaction with different sites of NMDA-receptors.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Benzothiadiazines / pharmacology
  • Cerebral Cortex / cytology
  • Cerebral Cortex / drug effects
  • Cerebral Cortex / metabolism
  • Excitatory Amino Acid Agonists / pharmacology
  • Excitatory Amino Acid Antagonists / pharmacology*
  • Indoles / pharmacology*
  • Kainic Acid / pharmacology
  • Memantine / pharmacology*
  • N-Methylaspartate / pharmacology
  • Neurons / drug effects
  • Neurons / metabolism*
  • Patch-Clamp Techniques
  • Purkinje Cells / cytology
  • Purkinje Cells / drug effects
  • Purkinje Cells / metabolism
  • Rats
  • Receptors, AMPA / drug effects
  • Receptors, AMPA / metabolism*
  • Receptors, N-Methyl-D-Aspartate / drug effects
  • Receptors, N-Methyl-D-Aspartate / metabolism*

Substances

  • Benzothiadiazines
  • Excitatory Amino Acid Agonists
  • Excitatory Amino Acid Antagonists
  • Indoles
  • Receptors, AMPA
  • Receptors, N-Methyl-D-Aspartate
  • N-Methylaspartate
  • latrepirdine
  • cyclothiazide
  • Kainic Acid
  • Memantine