Abstract
A sesquiterpene lactone, 1-O-acetyl-4R,6S-britannilactone (1) isolated from the flowers of Inula britannica L. var. chinensis (Rupr.) Reg. (Compositae), was found as an iNOS inhibitory constituent for the first time with an IC50 value of 22.1 microM which is more potent than the positive control, L-N6-(1-iminoethyl)lysine (IC50 = 33.7 microM). Structure of compound 1 was identified by 1D and 2D NMR experiments and by comparison with the reference standard.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Drug Evaluation, Preclinical / methods
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Flowers / chemistry
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Homoarginine / analogs & derivatives
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Homoarginine / pharmacology
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Inula*
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Lactones / chemistry
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Lactones / isolation & purification
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Lactones / pharmacology
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Lipopolysaccharides / antagonists & inhibitors
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Lipopolysaccharides / chemistry*
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Lipopolysaccharides / pharmacology*
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Medicine, East Asian Traditional
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Methanol
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Molecular Structure
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Nitric Oxide / antagonists & inhibitors*
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Nitric Oxide Synthase / chemistry*
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Nitric Oxide Synthase / isolation & purification
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Nitric Oxide Synthase / pharmacology
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Nitric Oxide Synthase Type II
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Plant Extracts / chemistry*
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Sesquiterpenes / chemistry
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Sesquiterpenes / isolation & purification
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Sesquiterpenes / pharmacology
Substances
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1-O-acetyl-4R,6S-britannilactone
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Lactones
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Lipopolysaccharides
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Plant Extracts
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Sesquiterpenes
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Homoarginine
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Nitric Oxide
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type II
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Methanol