Abstract
The activation of oncogenic transcription factors defines distinct molecular subsets of T-cell acute lymphoblastic leukaemia and has prognostic relevance in children. We investigated the prognostic effect of the expression levels of eight oncogenic transcription factors--TLX1 (HOX11), TLX3 (HOX11L2), TAL1, TAL2, LYL1, OLIG2 (BHLHB1), LMO1, and LMO2--in 52 adults with T-cell acute lymphoblastic leukaemia. The leukaemia-specific survival rate for the 16 TLX1-positive patients was 88% (90% CI 73-100%), compared with 56% (42-70%) for all other cases (p=0.019). Only the TLX1 oncogene expression subgroup showed difference in leukaemia-specific survival. Our results suggest that overexpression of TLX1 confers a good outlook for adults with T-cell acute lymphoblastic leukaemia. Furthermore, our findings lead to questions about whether stem-cell transplantation in first remission is necessary for effective treatment of patients in the low-risk subgroup of patients with TLX1 oncogene expression.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Adaptor Proteins, Signal Transducing
-
Adult
-
DNA-Binding Proteins / genetics
-
DNA-Binding Proteins / metabolism
-
Gene Expression Profiling
-
Gene Expression Regulation, Leukemic / genetics*
-
Homeodomain Proteins / genetics*
-
Homeodomain Proteins / metabolism
-
Humans
-
LIM Domain Proteins
-
Leukemia-Lymphoma, Adult T-Cell / genetics*
-
Leukemia-Lymphoma, Adult T-Cell / metabolism*
-
Leukemia-Lymphoma, Adult T-Cell / mortality
-
Metalloproteins / genetics
-
Metalloproteins / metabolism
-
Oncogene Proteins / genetics*
-
Oncogene Proteins / metabolism
-
Prognosis
-
Proto-Oncogene Proteins
-
Reverse Transcriptase Polymerase Chain Reaction
-
Survival Rate
-
Transcription Factors / genetics
-
Transcription Factors / metabolism
Substances
-
Adaptor Proteins, Signal Transducing
-
DNA-Binding Proteins
-
Homeodomain Proteins
-
LIM Domain Proteins
-
LMO2 protein, human
-
Metalloproteins
-
Oncogene Proteins
-
Proto-Oncogene Proteins
-
Transcription Factors
-
TLX1 protein, human