Solid phase synthesis of selective caspase-3 peptide inhibitors

Bioorg Med Chem. 2004 Mar 1;12(5):845-51. doi: 10.1016/j.bmc.2004.01.007.

Abstract

A robust method for the solid phase synthesis of a series of selective caspase-3 peptide inhibitors is described. The inhibitors can be obtained after cleavage from the solid support without further purification.

MeSH terms

  • Caspase 3
  • Caspase Inhibitors*
  • Cell Line
  • Cell Survival / drug effects
  • Combinatorial Chemistry Techniques
  • Enzyme Inhibitors / chemical synthesis
  • Enzyme Inhibitors / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Oligopeptides / chemical synthesis*
  • Oligopeptides / pharmacology*

Substances

  • Caspase Inhibitors
  • Enzyme Inhibitors
  • Oligopeptides
  • CASP3 protein, human
  • Caspase 3