Synthesis, biodistribution and micro-PET imaging of radiolabeled antimitotic agent T138067 analogues

Bioorg Med Chem Lett. 2004 Mar 8;14(5):1247-51. doi: 10.1016/j.bmcl.2003.12.061.

Abstract

Radiolabeled antimitotic agents [11C]T138067 and [18F]T138067 have been synthesized for evaluation as new potential positron emission tomography (PET) biomarkers for cancer imaging. In vivo biodistribution and micro-PET imaging of [11C]T138067 were performed in breast cancer animal models MCF-7 transfected with IL-1alpha implanted athymic mice and MDA-MB-435 implanted athymic mice. The results suggest that the uptakes of [11C]T138067 in both MCF-7 transfected with IL-1alpha tumor and MDA-MB-435 tumor are non-specific binding.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / metabolism*
  • Biological Availability
  • Carbon Radioisotopes / metabolism
  • Mice
  • Mice, Nude
  • Sulfonamides / chemical synthesis*
  • Sulfonamides / metabolism*
  • Tissue Distribution
  • Tomography, Emission-Computed / methods*
  • Xenograft Model Antitumor Assays / methods

Substances

  • Antineoplastic Agents
  • Carbon Radioisotopes
  • Sulfonamides
  • batabulin