A series of heterocyclic inhibitors of phenylalanyl-tRNA synthetases with antibacterial activity

Xiang Y Yu; John Finn; Jason M Hill; Zhong G Wang; Dennis Keith; Jared Silverman; N Oliver

doi:10.1016/j.bmcl.2003.11.082

A series of heterocyclic inhibitors of phenylalanyl-tRNA synthetases with antibacterial activity

Bioorg Med Chem Lett. 2004 Mar 8;14(5):1343-6. doi: 10.1016/j.bmcl.2003.11.082.

Authors

Xiang Y Yu¹, John Finn, Jason M Hill, Zhong G Wang, Dennis Keith, Jared Silverman, N Oliver

Affiliation

¹ Department of Medicinal Chemistry, Cubist Pharmaceuticals Inc., 24 Emily Street, Cambridge, MA 02139, USA. [email protected]

PMID: 14980695
DOI: 10.1016/j.bmcl.2003.11.082

Abstract

A series of novel heterocyclic analogues have been synthesized and evaluated for their ability to inhibit phenylalanyl-t-RNA synthetases and act as antibacterial agents. Several analogues have good antibacterial activity against Staphylococcus aureus.

Publication types

Comparative Study

MeSH terms

Anti-Bacterial Agents / chemistry*
Anti-Bacterial Agents / pharmacology
Enzyme Inhibitors / chemistry*
Enzyme Inhibitors / pharmacology
Heterocyclic Compounds / chemistry*
Heterocyclic Compounds / pharmacology
Microbial Sensitivity Tests / statistics & numerical data
Phenylalanine-tRNA Ligase / antagonists & inhibitors*
Phenylalanine-tRNA Ligase / metabolism

Substances

Anti-Bacterial Agents
Enzyme Inhibitors
Heterocyclic Compounds
Phenylalanine-tRNA Ligase