Alterations in morning cortisol associated with PTSD in women with breast cancer

J Psychosom Res. 2004 Jan;56(1):13-5. doi: 10.1016/S0022-3999(03)00561-0.

Abstract

Objective: Diagnosis and treatment of breast cancer can be a stressful experience, putting women at risk of posttraumatic stress disorder (PTSD). The current study investigated morning cortisol levels in newly diagnosed (i.e., within 6 months) breast cancer patients.

Methods: Structured DSM-IV interviews determined current and past incidence of PTSD and major depressive disorder (MDD) in 71 women with Stage 0-3 breast cancer.

Results: Significantly decreased plasma cortisol was found in women meeting current or lifetime criteria for PTSD or past diagnosis of MDD.

Conclusions: These results reinforce the importance for both psychological and physiological outcomes of a clinical evaluation of both current and past psychiatric status in newly diagnosed cancer patients.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Breast Neoplasms / blood*
  • Circadian Rhythm*
  • Comorbidity
  • Depressive Disorder, Major / blood
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / epidemiology
  • Diagnostic and Statistical Manual of Mental Disorders
  • Female
  • Humans
  • Hydrocortisone / blood*
  • Middle Aged
  • Prevalence
  • Severity of Illness Index
  • Stress Disorders, Post-Traumatic / blood*
  • Stress Disorders, Post-Traumatic / diagnosis
  • Stress Disorders, Post-Traumatic / epidemiology

Substances

  • Hydrocortisone