Ozz; a new name on the long list of beta-catenin's nemeses

Mol Cell. 2004 Feb 27;13(4):451-3. doi: 10.1016/s1097-2765(04)00090-5.

Abstract

In the February issue of Developmental Cell, Nastasi et al. describe Ozz, a muscle-specific ubiquitin ligase adaptor that regulates myofibril organization. Ozz appears to function in ubiquitination and degradation of membrane-bound, but not cytosolic, beta-catenin, whose turnover may be required for alignment and growth of the sarcomere, the basic contractile unit of myofibers.

Publication types

  • Review

MeSH terms

  • Adaptor Proteins, Vesicular Transport / metabolism*
  • Animals
  • Binding, Competitive
  • Cell Differentiation
  • Cell Membrane / metabolism
  • Cytoskeletal Proteins / chemistry
  • Cytoskeletal Proteins / metabolism*
  • Humans
  • Ligases / metabolism
  • Models, Biological
  • Muscle Proteins
  • Muscle, Skeletal / metabolism
  • Myocardium / metabolism
  • Myofibrils / metabolism
  • Sarcomeres / metabolism
  • Trans-Activators / chemistry
  • Trans-Activators / metabolism*
  • Ubiquitin / metabolism
  • Ubiquitin-Protein Ligase Complexes
  • Ubiquitin-Protein Ligases / metabolism
  • beta Catenin

Substances

  • Adaptor Proteins, Vesicular Transport
  • CTNNB1 protein, human
  • Cytoskeletal Proteins
  • Muscle Proteins
  • NEURL2 protein, human
  • Trans-Activators
  • Ubiquitin
  • beta Catenin
  • Ubiquitin-Protein Ligase Complexes
  • Ubiquitin-Protein Ligases
  • Ligases