Differential response of linear and angular psoralens in PUVA-induced apoptosis in HL-60 cells

Giampietro Viola; Laura Facciolo; Daniela Vedaldi; Silvia Disarò; Giuseppe Basso; Francesco Dall'Acqua

doi:10.1039/b313729e

Differential response of linear and angular psoralens in PUVA-induced apoptosis in HL-60 cells

Photochem Photobiol Sci. 2004 Mar;3(3):237-9. doi: 10.1039/b313729e. Epub 2004 Jan 28.

Authors

Giampietro Viola¹, Laura Facciolo, Daniela Vedaldi, Silvia Disarò, Giuseppe Basso, Francesco Dall'Acqua

Affiliation

¹ Department of Pharmaceutical Sciences, University of Padua, via Marzolo 5, 35131 Padua, Italy. [email protected]

PMID: 14993937
DOI: 10.1039/b313729e

Abstract

Treatment of cells with UVA radiation in combination with linear psoralens induces a cell-cycle block and subsequent apoptosis, whereas angular derivatives produce apoptosis without affecting the cellular cycle.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Apoptosis / drug effects*
Apoptosis / radiation effects
Cell Cycle / drug effects
Furocoumarins / chemistry*
Furocoumarins / pharmacology*
HL-60 Cells
Humans
PUVA Therapy
Photobiology
Photosensitizing Agents / chemistry
Photosensitizing Agents / pharmacology
Structure-Activity Relationship
Ultraviolet Rays

Substances

Furocoumarins
Photosensitizing Agents