Abstract
A new alkaloid, piperolactam E, and fourteen known compounds have been isolated from the stem of Piper taiwanense. Bioassay-guided fractionation of the methanolic extract led to the isolation, from the chloroform-soluble part, of 4-allylcatechol, eugenol, trans-caffeic aldehyde, 2-hydroxy-1-methoxy-4 H-dibenzo[ de,g]quinoline-4,5-(6 H)-dione, piperolactam B, piperolactam C, and piperolactam E as the active principles of anti-platelet aggregation in vitro. The derived 1,2-diacetoxy-4-allyl-benzene and eugenol acetate exhibit stronger anti-platelet aggregation activities induced by arachidonic acid than 4-allylcatechol and eugenol, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / administration & dosage
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Alkaloids / pharmacology
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Alkaloids / therapeutic use
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Animals
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Aristolochic Acids / chemistry
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Dose-Response Relationship, Drug
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Inhibitory Concentration 50
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Phytotherapy*
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Piper*
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Plant Extracts / administration & dosage
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Plant Extracts / pharmacology*
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Plant Extracts / therapeutic use
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Plant Stems
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Platelet Aggregation / drug effects*
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Platelet Aggregation Inhibitors / administration & dosage
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Platelet Aggregation Inhibitors / pharmacology*
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Platelet Aggregation Inhibitors / therapeutic use
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Rabbits
Substances
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Alkaloids
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Aristolochic Acids
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Plant Extracts
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Platelet Aggregation Inhibitors