Abstract
Bile acid-derived novel amphiphilic topology was designed and synthesized in the form of steroidal dimers. These dimers were tested for antifungal and antiproliferative activity in vitro. N(1),N(3)-Diethylenetriaminebis[cholic acid amide] was found to be active against C. albicans, Y. lipolytica, and B. poitrassi at nanomolar concentration and did not show any effect on cell proliferation. N(1),N(2)-Ethylenediaminebis[deoxycholic acid amide] totally inhibited the growth of human oral cancer (HEp-2) and human breast cancer (MCF-7) cells.
MeSH terms
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Antifungal Agents / chemical synthesis*
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Antifungal Agents / chemistry
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Antifungal Agents / pharmacology
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Bile Acids and Salts / chemistry*
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Candida albicans / drug effects
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Candida albicans / isolation & purification
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Cell Division / drug effects
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Cell Line
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Cell Line, Tumor
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Dimerization
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Drug Screening Assays, Antitumor
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Fungi / drug effects
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Humans
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Steroids / chemical synthesis*
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Steroids / chemistry
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Steroids / pharmacology
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Structure-Activity Relationship
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Yarrowia / drug effects
Substances
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Antifungal Agents
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Antineoplastic Agents
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Bile Acids and Salts
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Steroids