Increased expression of HIV co-receptor CXCR4 on CD4+ T-cells in patients with active visceral leishmaniasis

Scand J Infect Dis. 2004;36(1):56-8. doi: 10.1080/00365540310017546.

Abstract

Enhanced expression of the human immunodeficiency virus (HIV) co-receptor CXCR4 renders T-lymphocytes more susceptible for infection with HIV. We demonstrate that patients with active visceral leishmaniasis have a higher proportion of circulating CD4+ T-cells expressing CXCR4 than healthy controls, suggesting that Leishmania may facilitate HIV infection of CD4+ lymphocytes.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Analysis of Variance
  • Biomarkers / analysis
  • CD4-Positive T-Lymphocytes
  • Child
  • Cohort Studies
  • Comorbidity
  • Female
  • HIV Infections / diagnosis
  • HIV Infections / epidemiology*
  • Humans
  • Incidence
  • Leishmaniasis, Visceral / diagnosis
  • Leishmaniasis, Visceral / epidemiology*
  • Male
  • Netherlands / epidemiology
  • Probability
  • Receptors, CXCR4 / analysis*
  • Receptors, HIV / analysis*
  • Risk Factors
  • Sensitivity and Specificity
  • Viral Load

Substances

  • Biomarkers
  • Receptors, CXCR4
  • Receptors, HIV