Safety and immunogenicity of a booster dose of Vibrio cholerae CVD 103-HgR live oral cholera vaccine in Swiss adults

S J Cryz Jr; M M Levine; G Losonsky; J B Kaper; B Althaus

doi:10.1128/iai.60.9.3916-3917.1992

Safety and immunogenicity of a booster dose of Vibrio cholerae CVD 103-HgR live oral cholera vaccine in Swiss adults

Infect Immun. 1992 Sep;60(9):3916-7. doi: 10.1128/iai.60.9.3916-3917.1992.

Authors

S J Cryz Jr¹, M M Levine, G Losonsky, J B Kaper, B Althaus

Affiliation

¹ Swiss Serum and Vaccine Institute, CH-3001 Berne.

Abstract

Adult volunteers received a booster dose (4 x 10(8) CFU) of attenuated Vibrio cholerae CVD 103-HgR oral vaccine 15 or 24 months after primary immunization. The immune response was modest, presumably due to rapid clearance of the vaccine strain by a primed immune system.

MeSH terms

Administration, Oral
Adult
Antibodies, Bacterial / analysis
Cholera Vaccines / immunology*
Cholera Vaccines / toxicity
Humans
Immunization, Secondary
Middle Aged
Vaccines, Attenuated / immunology

Substances

Antibodies, Bacterial
Cholera Vaccines
Vaccines, Attenuated