The aim of this paper was to analyse how the strategies implemented by the Central Nervous System to control the hand during grasping are modified under microgravity conditions. Two right-handed subjects carried out simple grasping tasks during parabolic flights. The trajectories of the fingers of the hand were recorded using a sensorised glove and processed in order to extract a variable (here indicated as K) which can indicated the degree of synergies existing among the fingers. The results showed that K was quite small during the trial at 1g while becoming significantly greater than 1 during the first parabolas. Then, the value k decreased to the values at 1 g after some parabolas. These results suggested a possible adaptation process of the manipulation abilities during the permanence at 0g conditions. Future extensive trials will be performed in order to confirm these preliminary results.