Using Caenorhabditis elegans to probe toxicity of 1-alkyl-3-methylimidazolium chloride based ionic liquids

Richard P Swatloski; John D Holbrey; Shermeen B Memon; Guy A Caldwell; Kim A Caldwell; Robin D Rogers

doi:10.1039/b316491h

Using Caenorhabditis elegans to probe toxicity of 1-alkyl-3-methylimidazolium chloride based ionic liquids

Chem Commun (Camb). 2004 Mar 21:(6):668-9. doi: 10.1039/b316491h. Epub 2004 Feb 10.

Authors

Richard P Swatloski¹, John D Holbrey, Shermeen B Memon, Guy A Caldwell, Kim A Caldwell, Robin D Rogers

Affiliation

¹ Department of Chemistry and Center for Green Manufacturing, The University of Alabama, Tuscaloosa, 35487, USA.

PMID: 15010772
DOI: 10.1039/b316491h

Abstract

Ionic liquids are gaining attention as new solvents within the green chemistry community; however this attention has quickly outstripped current environmental and toxicological data available. In the present communication, we establish the use of Caenorhabditis elegans as a model organism for inexpensively and quickly exploring toxicological effects of 1-alkyl-3-methylimidazolium chloride ionic liquids.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Biological Assay / methods*
Caenorhabditis elegans / drug effects*
Caenorhabditis elegans / physiology
Imidazoles / toxicity*
Ions / toxicity*
Nematoda / drug effects
Nematoda / physiology
Solvents / toxicity*
Toxicity Tests / methods*

Substances

Imidazoles
Ions
Solvents