Abstract
We report the synthesis of new guanylhydrazones from imidazo[2,1-b]thiazoles and of a bis-guanylhydrazone from diimidazo[1,2-a:1,2-c]pyrimidine. The compounds were tested as potential antitumor agents at the National Cancer Institute. Two derivatives are now under review by BEC: one of these was also subjected to a test for positive inotropic activity in view of a possible coanthracyclinic activity. Tyrosine kinase receptors may be involved as molecular targets in the mechanism of action of the guanylhydrazones described.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Guanidines / chemical synthesis
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Guanidines / pharmacology
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Humans
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Hydrazones / chemistry*
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Hydrazones / pharmacology*
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Imidazoles / chemistry*
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Molecular Structure
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Pyrimidines / chemistry*
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Thiazoles / chemistry*
Substances
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Antineoplastic Agents
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Guanidines
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Hydrazones
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Imidazoles
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Pyrimidines
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Thiazoles