High frequency of mutations of the PIK3CA gene in human cancers

Science. 2004 Apr 23;304(5670):554. doi: 10.1126/science.1096502. Epub 2004 Mar 11.

Authors

Yardena Samuels¹, Zhenghe Wang, Alberto Bardelli, Natalie Silliman, Janine Ptak, Steve Szabo, Hai Yan, Adi Gazdar, Steven M Powell, Gregory J Riggins, James K V Willson, Sanford Markowitz, Kenneth W Kinzler, Bert Vogelstein, Victor E Velculescu

Affiliation

¹ Sidney Kimmel Comprehensive Cancer Center, Howard Hughes Medical Institute, The Johns Hopkins University Medical Institutions, Baltimore, MD 21231, USA.

PMID: 15016963
DOI: 10.1126/science.1096502

No abstract available

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Breast Neoplasms / genetics
Catalytic Domain
Class I Phosphatidylinositol 3-Kinases
Colorectal Neoplasms / genetics
Glioblastoma / genetics
Humans
Lung Neoplasms / genetics
Mutation*
Neoplasms / genetics*
Phosphatidylinositol 3-Kinases / genetics*
Phosphatidylinositol 3-Kinases / metabolism
Sequence Analysis, DNA
Stomach Neoplasms / genetics

Substances

Phosphatidylinositol 3-Kinases
Class I Phosphatidylinositol 3-Kinases
PIK3CA protein, human

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