Paradoxical sleep deprivation potentiates amphetamine-induced behavioural sensitization by increasing its conditioned component

Roberto Frussa-Filho; Michele Themis Moraes Gonçalves; Monica Levy Andersen; Nilza Pereira de Araujo; Cibele Cristina Chinen; Sergio Tufik

doi:10.1016/j.brainres.2003.11.050

Paradoxical sleep deprivation potentiates amphetamine-induced behavioural sensitization by increasing its conditioned component

Brain Res. 2004 Apr 2;1003(1-2):188-93. doi: 10.1016/j.brainres.2003.11.050.

Authors

Roberto Frussa-Filho¹, Michele Themis Moraes Gonçalves, Monica Levy Andersen, Nilza Pereira de Araujo, Cibele Cristina Chinen, Sergio Tufik

Affiliation

¹ Departamento de Farmacologia, Universidade Federal de São Paulo, Rua Botucatu, 862, Edificio Leal Prado, CEP 04023-062, São Paulo, SP, Brazil.

PMID: 15019579
DOI: 10.1016/j.brainres.2003.11.050

Abstract

The effects of paradoxical sleep deprivation (PSD-48 h) on the conditioned and unconditioned components of behavioural sensitization to amphetamine (two injections of 2.0 mg/kg, separated by 7 days) were studied using locomotion frequency of mice observed in an open-field as experimental parameter. Behavioural sensitization only occurred in PS deprived mice that were exposed to the open-field after the first amphetamine injection. The possible involvement of PSD in the development of a Pavlovian association between the stimulant effect of amphetamine and environmental as well as interoceptive drug cues is discussed.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Amphetamine / pharmacology*
Animals
Conditioning, Psychological / drug effects*
Conditioning, Psychological / physiology
Male
Mice
Mice, Inbred C57BL
Motor Activity / drug effects*
Motor Activity / physiology
Sleep Deprivation* / physiopathology
Sleep, REM / drug effects*
Sleep, REM / physiology

Substances

Amphetamine