Abstract
A quantitative structure-activity relationship (QSAR) study was performed on a set of 49 negative allosteric modulators of AMPA receptor, acting as anticonvulsant agents, using multiple linear regression. The predictive ability of the resulting model was evaluated against a set of 12 compounds; the results showed good statistics in regression and revealed high correlation between anticonvulsant activity and some electrotopological descriptors.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Allosteric Regulation
-
Anticonvulsants / chemistry*
-
Anticonvulsants / pharmacokinetics
-
Anticonvulsants / pharmacology
-
Benzodiazepines / chemistry
-
Benzodiazepines / pharmacokinetics
-
Benzodiazepines / pharmacology
-
Excitatory Amino Acid Antagonists / chemistry*
-
Excitatory Amino Acid Antagonists / pharmacokinetics
-
Excitatory Amino Acid Antagonists / pharmacology
-
Isoquinolines / chemistry
-
Isoquinolines / pharmacokinetics
-
Isoquinolines / pharmacology
-
Linear Models
-
Models, Biological
-
Phthalazines / chemistry
-
Phthalazines / pharmacokinetics
-
Phthalazines / pharmacology
-
Quantitative Structure-Activity Relationship
-
Receptors, AMPA / antagonists & inhibitors*
-
Receptors, AMPA / chemistry
Substances
-
Anticonvulsants
-
Excitatory Amino Acid Antagonists
-
Isoquinolines
-
Phthalazines
-
Receptors, AMPA
-
Benzodiazepines