The inducible NO synthase is downregulated during apoptosis of malignant cells from B-cell chronic lymphocytic leukemia induced by flavopiridol and polyphenols

Ann N Y Acad Sci. 2003 Dec:1010:381-3. doi: 10.1196/annals.1299.069.

Abstract

Downregulation of iNOS and NO is a pathway common for flavones and polyphenols, two distinct families of phytoalexins. Our data suggest that inhibition of the NO pathway could be one of the mechanisms involved in the proapoptotic properties of these phytoalexins in leukemia B-cells.

MeSH terms

  • Antineoplastic Agents / toxicity
  • Apoptosis / drug effects*
  • Apoptosis / genetics
  • Cell Line, Tumor
  • Flavonoids / pharmacology*
  • Flavonoids / toxicity*
  • Gene Expression Regulation, Enzymologic / drug effects
  • Gene Expression Regulation, Neoplastic / drug effects*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / enzymology
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Nitric Oxide Synthase / genetics*
  • Nitric Oxide Synthase Type II
  • Phenols / pharmacology*
  • Piperidines / toxicity*
  • Polyphenols

Substances

  • Antineoplastic Agents
  • Flavonoids
  • Phenols
  • Piperidines
  • Polyphenols
  • alvocidib
  • NOS2 protein, human
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type II