Abstract
It is known that hyperplastic alveolar nodule (HAN) is a representative preneoplastic state in mammary glands of mice. We examined the effect of 1-(2-tetrahydrofuryl)-5-fluorouracil and uracil (UFT) on HAN formation in a high mammary tumour strain of SHN virgin mice. Oral administration of UFT for 5 months beginning at one month of age significantly reduced the number of HAN and DNA-synthesizing enzyme activities in the mammary glands. These results indicate that long-term administration of low dose UFT reduces the de novo and salvage synthesis of DNA and suppresses preneoplastic HAN.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Female
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Growth / drug effects
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Hyperplasia / drug therapy
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Hyperplasia / enzymology
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Mammary Glands, Animal / enzymology
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Mammary Glands, Animal / pathology*
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Mammary Neoplasms, Animal / drug therapy*
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Mammary Neoplasms, Animal / enzymology
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Mice
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Mice, Inbred Strains
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Precancerous Conditions / drug therapy*
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Precancerous Conditions / enzymology
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Tegafur / administration & dosage
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Tegafur / therapeutic use*
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Thymidine Kinase / metabolism
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Thymidylate Synthase / metabolism
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Uracil / therapeutic use*
Substances
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Tegafur
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Uracil
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Thymidylate Synthase
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Thymidine Kinase