Abstract
Antigenic modulation of major histocompatibility and tumour associated antigens was observed in neoplastic cells obtained from patients with pleural and abdominal effusions of breast and ovary carcinomas following a single intracavitary dose of 18 x 10(6) U recombinant IFN-alpha. This regimen resulted in antigenic modulation in seven out of 11 tested cases, suggesting a potential, although limited, responsiveness of at least a fraction of breast and ovary carcinoma cells to in situ biomodification with IFN-alpha.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antibodies, Monoclonal
-
Antigens, Neoplasm / analysis*
-
Ascites / immunology
-
Breast Neoplasms / immunology*
-
Breast Neoplasms / therapy
-
Enzyme-Linked Immunosorbent Assay
-
Female
-
HLA-D Antigens / analysis*
-
Histocompatibility Antigens Class I / analysis*
-
Humans
-
Interferon Type I / therapeutic use*
-
Ovarian Neoplasms / immunology*
-
Ovarian Neoplasms / therapy
-
Pleural Effusion, Malignant / immunology
-
Recombinant Proteins
Substances
-
Antibodies, Monoclonal
-
Antigens, Neoplasm
-
HLA-D Antigens
-
Histocompatibility Antigens Class I
-
Interferon Type I
-
Recombinant Proteins