We report combined trabeculectomy and vitrectomy in a 66-year-old woman with combined-mechanism glaucoma. Trabeculectomy supplemented with mitomycin-C was done first. Before the scleral and conjunctival flap were sutured, an anterior vitrectomy was performed via the peripheral iridectomy until a pathway between the anterior chamber and aqueous pool in the vitreous cavity was established. One day postoperatively, the intraocular pressure (IOP) was 10 mm Hg. Six months later, the IOP was 13 mm Hg and the bleb remained formed.