Antimalarial activities of (+)-deoxoartemisitene and its novel C-11, 13 derivatives

Mankil Jung; Kyunghoon Lee; Hochul Jung; Howard Kendrick; Vanessa Yardley; Simon L Croft

doi:10.1016/j.bmcl.2003.12.104

Antimalarial activities of (+)-deoxoartemisitene and its novel C-11, 13 derivatives

Bioorg Med Chem Lett. 2004 Apr 19;14(8):2001-3. doi: 10.1016/j.bmcl.2003.12.104.

Authors

Mankil Jung¹, Kyunghoon Lee, Hochul Jung, Howard Kendrick, Vanessa Yardley, Simon L Croft

Affiliation

¹ Department of Chemistry, Yonsei University, Seoul 120-749, South Korea. [email protected]

PMID: 15050646
DOI: 10.1016/j.bmcl.2003.12.104

Abstract

(+)-Deoxoartemisitene and its C-11, 13 derivatives were synthesized from artemisinic acid via a short and regiospecific process and several derivatives show 10-20 times more in vitro antimalarial activities against Plasmodium falciparum than artemisinin.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antimalarials / chemical synthesis*
Antimalarials / chemistry
Antimalarials / pharmacology*
Artemisinins / chemical synthesis*
Artemisinins / chemistry
Artemisinins / pharmacology*
Drug Evaluation, Preclinical
Molecular Structure
Plasmodium falciparum / drug effects*

Substances

Antimalarials
Artemisinins
deoxoartemisitene