Although chondrosarcoma is a relatively common malignant bone lesion, these lesions rarely affect the foot. This article presents the case of a 32-year-old woman with a chondrosarcoma in the distal phalanx of the right second toe. Radiography and computed tomography showed cortical disruption and soft-tissue expansion. Histologically, the tumor was classified as grade 2 chondrosarcoma according to the American Joint Committee of Cancer pathologic staging system. Amputation at the distal half of the second proximal phalanx was performed to obtain clear surgical margins. A literature review and discussion of salient diagnostic and treatment issues is included.