Sonographic findings in Beckwith-Wiedemann syndrome related to H19 hypermethylation

Prenat Diagn. 2004 Mar;24(3):165-8. doi: 10.1002/pd.818.

Abstract

Beckwith-Wiedemann syndrome (BWS) is an overgrowth syndrome associated with congenital malformations and tumour predisposition. BWS results from variable mutations or epigenetic modifications of imprinted genes in the 11p15 chromosomal region. We present a fetus with mild general overgrowth and bilateral enlarged echogenic kidneys with loss of the corticomedullary differentiation in which prenatal diagnosis of BWS was suspected. The rest of the fetal anatomy and the amniotic fluid volume appeared normal. After termination of the pregnancy, molecular analysis confirmed the diagnosis of BWS by showing an isolated hypermethylation of the H19 gene.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Beckwith-Wiedemann Syndrome / diagnostic imaging*
  • Beckwith-Wiedemann Syndrome / genetics
  • Beckwith-Wiedemann Syndrome / pathology
  • Chromosomes, Human, Pair 11*
  • DNA Methylation*
  • Female
  • Fetal Diseases / diagnostic imaging*
  • Fetal Diseases / genetics
  • Humans
  • Pregnancy
  • RNA, Long Noncoding
  • RNA, Untranslated / metabolism*
  • Ultrasonography, Prenatal*

Substances

  • H19 long non-coding RNA
  • RNA, Long Noncoding
  • RNA, Untranslated