Leiden mutation, bed rest and infection: simultaneous triggers for maternal deep-vein thrombosis and neonatal intracranial hemorrhage?

Fetal Diagn Ther. 2004 May-Jun;19(3):275-7. doi: 10.1159/000076711.

Abstract

The possible etiologic roles of infection and bed rest are discussed in connection with a case of maternal homozygous Leiden mutation leading to prematurity, maternal deep-vein thrombosis and neonatal intracranial hemorrhage in a heterozygous premature baby. Maternal bacterial infection and bed rest may trigger deep-vein femoral thrombosis in women with a homozygous Leiden mutation on tocolytic therapy for the treatment of premature labor. The neonate carrying at least one mutated allele of factor V Leiden might be at risk for the development of intracranial hemorrhage.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bacterial Infections / complications*
  • Bed Rest / adverse effects*
  • Cerebral Hemorrhage / etiology
  • Cerebral Hemorrhage / genetics*
  • Factor V*
  • Female
  • Femoral Vein*
  • Genetic Predisposition to Disease
  • Homozygote
  • Humans
  • Infant, Newborn
  • Obstetric Labor, Premature / drug therapy
  • Point Mutation
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / etiology*
  • Pregnancy Complications, Infectious*
  • Tocolytic Agents / adverse effects
  • Tocolytic Agents / therapeutic use
  • Venous Thrombosis / etiology
  • Venous Thrombosis / genetics*

Substances

  • Tocolytic Agents
  • factor V Leiden
  • Factor V