Abstract
The development of new strategies for solid-phase synthesis of 3-aza-6,8-dioxabicyclo[3.2.1]octane scaffolds, named BTKa, is described. The preparation was made possible by the combination of three components: amines, alpha-halo-acetophenones, and sugar or tartaric acid derivatives. By anchoring each of the three components it was possible to synthesize BTKa compounds either as amino alcohols or amido esters. The compatibility of the protocols with different classes of amines and substituted alpha-halo-acetophenones was demonstrated.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetophenones / chemistry
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Acetophenones / metabolism
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Alcohols / chemistry
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Amines / chemistry
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Amines / metabolism
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Amino Alcohols / chemistry
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Amino Alcohols / metabolism
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Aza Compounds / chemical synthesis*
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Aza Compounds / chemistry
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Esters / chemistry
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Molecular Structure
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Octanes / chemical synthesis*
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Octanes / chemistry
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Tartrates / chemistry
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Tartrates / metabolism
Substances
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Acetophenones
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Alcohols
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Amines
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Amino Alcohols
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Aza Compounds
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Esters
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Octanes
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Tartrates
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tartaric acid
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octane