Abstract
Penile cancer is rare in Western countries. High-risk patients are considered for prophylactic inguinal lymphadenectomy. For advanced disease, a triplet drug regimen consisting of bleomycin, methotrexate, and cisplatin is the most active combination tested so far. A 62-year-old man with penile cancer underwent partial penile amputation but presented 10 months later with inguinal nodal metastasis. He received three cycles of paclitaxel/carboplatin with marked clinical and radiologic (computed tomography and positron emission tomography) tumor regression. Later, complete resection of the inguinal nodal metastasis was performed. The paclitaxel/carboplatin combination has potential activity in penile cancer. Positron emission tomography may be used for screening of nodal metastases.
MeSH terms
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Antineoplastic Agents, Phytogenic / therapeutic use
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Carboplatin / therapeutic use*
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Carcinoma, Squamous Cell / drug therapy*
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Carcinoma, Squamous Cell / pathology
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Combined Modality Therapy
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Fluorodeoxyglucose F18
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Humans
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Lymph Node Excision / methods
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Lymph Nodes / diagnostic imaging
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Lymph Nodes / pathology
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Lymph Nodes / surgery
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Lymphatic Metastasis / diagnostic imaging*
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Lymphatic Metastasis / pathology
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Male
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Middle Aged
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Paclitaxel / therapeutic use*
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Penile Neoplasms / drug therapy*
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Penile Neoplasms / pathology
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Penile Neoplasms / surgery
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Penis / surgery
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Remission Induction / methods
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Survival Analysis
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Tomography, Emission-Computed
Substances
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Antineoplastic Agents, Phytogenic
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Fluorodeoxyglucose F18
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Carboplatin
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Paclitaxel