Molecular monitoring to identify a threshold of CBFbeta/MYH11 transcript below which continuous complete remission of acute myeloid leukemia inv16 is likely

Giovanni Martinelli; Michela Rondoni; Silvia Buonamici; Emanuela Ottaviani; Pier Paolo Piccaluga; Michele Malagola; Michele Baccarani

Molecular monitoring to identify a threshold of CBFbeta/MYH11 transcript below which continuous complete remission of acute myeloid leukemia inv16 is likely

Haematologica. 2004 Apr;89(4):495-7.

Authors

Giovanni Martinelli, Michela Rondoni, Silvia Buonamici, Emanuela Ottaviani, Pier Paolo Piccaluga, Michele Malagola, Michele Baccarani

PMID: 15075086

Abstract

Many patients with the inv(16) positive acute myeloid leukemia (AML) achieve complete remission (CR). Using real-time reverse transcriptase polymerase chain reaction (RT-PCR), we previously proposed critical CBFbeta-MYH11 transcript copy number thresholds to predict relapse or cure. We now update the molecular follow-up of our patients, also presenting the therapeutic management of these patients.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Acute Disease
Adolescent
Adult
Chromosome Inversion
Chromosomes, Human, Pair 16
Female
Humans
Leukemia, Myeloid / diagnosis*
Leukemia, Myeloid / genetics
Male
Middle Aged
Neoplasm, Residual / diagnosis
Oncogene Proteins, Fusion / genetics*
RNA, Messenger / analysis*
Remission Induction
Retrospective Studies

Substances

CBFbeta-MYH11 fusion protein
Oncogene Proteins, Fusion
RNA, Messenger