Reduction of mitochondrial DNA content and respiratory chain activity occurs in adipocytes within 6-12 months of commencing nucleoside reverse transcriptase inhibitor therapy

MeSH terms

• Adipocytes / drug effects
• Adipocytes / metabolism
• Adipocytes / ultrastructure*
• DNA, Mitochondrial / analysis*
• DNA, Mitochondrial / drug effects
• Electron Transport
• Electron Transport Complex IV / metabolism
• HIV Infections / drug therapy*
• HIV Infections / metabolism
• HIV Infections / pathology
• HIV-1*
• Humans
• Reverse Transcriptase Inhibitors / adverse effects*
• Reverse Transcriptase Inhibitors / therapeutic use
• Time Factors