Abstract
Antiplatelet drugs (APD) are widely used in the prevention of ischemic cardio- and cerebrovascular diseases. The authors studied the frequency of stroke occurring after APD discontinuation, the cause of discontinuation, and the delay between APD disruption and stroke. Only 4.49% of strokes were related to a recent APD discontinuation, but all cases occurred between 6 and 10 days after drug discontinuation (p < 0.0001). This temporal pattern has biologic plausibility because the inhibited platelets circulate in the blood for about 10 days.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Brain Ischemia / chemically induced*
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Brain Ischemia / epidemiology*
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Causality
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Cerebral Hemorrhage / chemically induced
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Cerebral Hemorrhage / epidemiology
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Cohort Studies
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Comorbidity
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Female
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France / epidemiology
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Humans
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Ischemic Attack, Transient / chemically induced
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Ischemic Attack, Transient / epidemiology
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Male
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Middle Aged
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Platelet Aggregation Inhibitors / adverse effects*
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Prospective Studies
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Risk Factors
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Stroke / chemically induced*
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Stroke / epidemiology*
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Substance Withdrawal Syndrome / epidemiology*
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Time Factors
Substances
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Platelet Aggregation Inhibitors