Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum

Vinod R Hegde; Haiyan Pu; Mahesh Patel; Todd Black; Aileen Soriano; Wenjun Zhao; Vincent P Gullo; Tze-Ming Chan

doi:10.1016/j.bmcl.2004.02.006

Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum

Bioorg Med Chem Lett. 2004 May 3;14(9):2275-7. doi: 10.1016/j.bmcl.2004.02.006.

Authors

Vinod R Hegde¹, Haiyan Pu, Mahesh Patel, Todd Black, Aileen Soriano, Wenjun Zhao, Vincent P Gullo, Tze-Ming Chan

Affiliation

¹ Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. [email protected]

PMID: 15081024
DOI: 10.1016/j.bmcl.2004.02.006

Abstract

The 70% aqueous methanolic extract of the Peruvian plant Polygonum cuspidatum sp. was found to contain two novel phenolic saccharides 1 and 2, which were identified as inhibitors of the bacterial DNA primase enzyme. Structures of these two compounds were established based on high resolution NMR studies. Compound 1 and 2 inhibited the primase enzyme with an IC(50) of 4 and 5 microM, respectively.

MeSH terms

Bacteria / enzymology*
DNA Primase / antagonists & inhibitors*
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / isolation & purification
Enzyme Inhibitors / pharmacology*
Fallopia japonica / chemistry*
Spectrum Analysis

Substances

Enzyme Inhibitors
DNA Primase