Synthesis of a novel peptidic photoaffinity probe for the PTP-1B enzyme

Bioorg Med Chem Lett. 2004 May 3;14(9):2319-22. doi: 10.1016/j.bmcl.2004.01.101.

Abstract

The synthesis of a novel radioactive peptidic photoaffinity probe for the PTP-1B enzyme as well as some SAR leading to the choice of this compound as a photoaffinity probe are presented.

MeSH terms

  • Photoaffinity Labels / chemical synthesis*
  • Photoaffinity Labels / chemistry
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Protein Tyrosine Phosphatases / chemistry*

Substances

  • Photoaffinity Labels
  • Protein Tyrosine Phosphatase, Non-Receptor Type 1
  • Protein Tyrosine Phosphatases