Abstract
Sydenham's chorea (SC) is thought to result from the action of streptococcus-induced antibodies that cross react with basal ganglia antigens. Much less is known, however, about the involvement of cellular mechanisms in its pathogenesis. Since chemokines seem to play a role in several CNS inflammatory disorders, we sought to investigate the chemokine profile of patients with SC. Increased serum levels of CXCL9, formerly monokine induced by interferon-gamma (Mig), and CXCL10, formerly interferon-gamma-inducible protein of 10 kDa (IP-10) were demonstrated in acute SC patients, suggesting that a particular group of chemokines may be involved in SC pathogenesis.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Acute Disease
-
Adolescent
-
Adult
-
Chemokine CXCL10
-
Chemokine CXCL9
-
Chemokines, CXC / blood*
-
Chemokines, CXC / cerebrospinal fluid
-
Child
-
Chorea / blood
-
Chorea / cerebrospinal fluid
-
Chorea / immunology*
-
Female
-
Humans
-
Inflammation Mediators / blood
-
Inflammation Mediators / cerebrospinal fluid
-
Intercellular Signaling Peptides and Proteins / blood*
-
Intercellular Signaling Peptides and Proteins / cerebrospinal fluid
-
Male
-
Middle Aged
-
Up-Regulation / immunology
Substances
-
CXCL9 protein, human
-
Chemokine CXCL10
-
Chemokine CXCL9
-
Chemokines, CXC
-
Inflammation Mediators
-
Intercellular Signaling Peptides and Proteins