Abstract
Interactions between ectodermal and mesenchymal extracellular signaling pathways regulate hair follicle (HF) morphogenesis and hair cycling. Bone morphogenetic proteins (BMPs) are known to be important in hair follicle development by affecting the local cell fate modulation. To study the role of BMP signaling in the HF, we disrupted Bmpr1a, which encodes the BMP receptor type IA (BMPR1A) in an HF cell-specific manner, using the Cre/loxP system. We found that the differentiation of inner root sheath, but not outer root sheath, was severely impaired in mutant mice. The number of HFs was reduced in the dermis and subcutaneous tissue, and cycling epithelial cells were reduced in mutant mice HFs. Our results strongly suggest that BMPR1A signaling is essential for inner root sheath differentiation and is indispensable for HF renewal in adult skin.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bone Morphogenetic Protein Receptors, Type I
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Cell Differentiation / physiology*
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Cytoskeletal Proteins / biosynthesis
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Cytoskeletal Proteins / genetics
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Hair Follicle / abnormalities
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Hair Follicle / pathology
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Hair Follicle / physiology*
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Hedgehog Proteins
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Integrases / genetics
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Integrases / metabolism
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Mice
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Mice, Knockout
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / physiology*
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Receptors, Growth Factor / genetics
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Receptors, Growth Factor / physiology*
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Signal Transduction / physiology*
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Trans-Activators / biosynthesis
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Trans-Activators / genetics
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Viral Proteins / genetics
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Viral Proteins / metabolism
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beta Catenin
Substances
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CTNNB1 protein, mouse
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Cytoskeletal Proteins
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Hedgehog Proteins
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Receptors, Growth Factor
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Shh protein, mouse
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Trans-Activators
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Viral Proteins
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beta Catenin
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Protein Serine-Threonine Kinases
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Bmpr1a protein, mouse
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Bone Morphogenetic Protein Receptors, Type I
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Cre recombinase
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Integrases