Abstract
Lipogenesis is regulated by sterols and by insulin through the regulated expression and activation of the sterol regulatory element-binding proteins (SREBPs). A new study shows one way in which sterol and insulin regulation can be decoupled. In transgenic mice overexpressing a protein that regulates SREBP activation, lipogenesis is more sensitive to cholesterol and less sensitive to insulin.
MeSH terms
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Animals
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CCAAT-Enhancer-Binding Proteins / physiology
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DNA-Binding Proteins / physiology
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Insulin / pharmacology*
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Insulin Resistance
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Intracellular Signaling Peptides and Proteins
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Lipids / biosynthesis*
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Membrane Proteins / physiology*
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Mice
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Mice, Transgenic
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Sterol Regulatory Element Binding Protein 1
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Transcription Factors*
Substances
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CCAAT-Enhancer-Binding Proteins
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DNA-Binding Proteins
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INSIG1 protein, human
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Insulin
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Intracellular Signaling Peptides and Proteins
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Lipids
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Membrane Proteins
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Srebf1 protein, mouse
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Sterol Regulatory Element Binding Protein 1
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Transcription Factors