Abstract
Anergy is a mechanism of T lymphocyte tolerance induced by antigen receptor stimulation in the absence of co-stimulation. Anergic T cells were shown to have a defect in antigen-induced transcription of the interleukin-2 gene. Analysis of the promoter indicated that the transcription factor AP-1 and its corresponding cis element were specifically down-regulated. Exposure of anergic T cells to interleukin-2 restored both antigen responsiveness and activity of the AP-1 element.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, P.H.S.
MeSH terms
-
Animals
-
Antigen-Presenting Cells / immunology
-
Antigens / immunology*
-
Base Sequence
-
Binding Sites
-
Blotting, Northern
-
Cell Line
-
Concanavalin A / pharmacology
-
Gene Expression Regulation*
-
Immune Tolerance*
-
Interleukin-2 / genetics*
-
Interleukin-2 / pharmacology
-
Mice
-
Molecular Sequence Data
-
Mutation
-
Promoter Regions, Genetic / genetics
-
Proto-Oncogene Proteins c-jun / physiology*
-
RNA, Messenger / metabolism
-
Receptors, Antigen, T-Cell / immunology
-
T-Lymphocytes / immunology*
-
Transcription, Genetic
-
Transfection
Substances
-
Antigens
-
Interleukin-2
-
Proto-Oncogene Proteins c-jun
-
RNA, Messenger
-
Receptors, Antigen, T-Cell
-
Concanavalin A