Thymidylate synthase as an oncogene?

J R Bertino; D Banerjee

doi:10.1016/s1535-6108(04)00086-8

Thymidylate synthase as an oncogene?

Cancer Cell. 2004 Apr;5(4):301-2. doi: 10.1016/s1535-6108(04)00086-8.

Authors

J R Bertino¹, D Banerjee

Affiliation

¹ Cancer Institute of New Jersey, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, 195 Little Albany Street, New Brunswick, NJ 08903, USA. [email protected]

PMID: 15093534
DOI: 10.1016/s1535-6108(04)00086-8

Abstract

A surprising finding in the report by Rahman et al. in this issue of Cancer Cell is that forced overexpression of human thymidylate synthase transforms immortalized murine cells into a malignant phenotype. We discuss the possibility that elevated levels of thymidylate synthase noted in some human malignancies may contribute to tumor progression and may also reflect increased levels of its transcriptional activator E2F-1.

Publication types

Comment
Editorial

MeSH terms

Animals
Apoptosis
Cell Cycle Proteins*
Cell Transformation, Neoplastic
DNA-Binding Proteins / metabolism
Disease Progression
E2F Transcription Factors
E2F1 Transcription Factor
Humans
Mice
Neoplasms / enzymology*
Oncogenes / physiology*
Thymidylate Synthase / physiology*
Transcription Factors / metabolism

Substances

Cell Cycle Proteins
DNA-Binding Proteins
E2F Transcription Factors
E2F1 Transcription Factor
E2F1 protein, human
E2f1 protein, mouse
Transcription Factors
Thymidylate Synthase