Abstract
We established persistent infection with a strain of human immunodeficiency type 1, HTLV-IIIB, in a ++promyelo-monocytic cell line, ML-1 (CD4 antigen nearly negative and CD4 mRNA negative), and a promonocytic cell line, THP-1 (CD4 antigen positive). Different reactions of giant cell formation were found after cocultivation of infected and uninfected cells of ML-1, HL-60, THP-1 and U-937 cell lines with uninfected and infected MOLT4 (a T-lymphoma cell line). Factors affecting the cellular tropism of human immunodeficiency virus were discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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AIDS Dementia Complex / blood
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AIDS Dementia Complex / immunology
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AIDS Dementia Complex / pathology*
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Brain / immunology
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Brain / pathology*
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CD4 Antigens / analysis
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CD4 Antigens / immunology
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Cell Line
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Cell Membrane / immunology
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Cell Membrane / microbiology
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Cell Membrane / ultrastructure
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Encephalitis / blood
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Encephalitis / immunology
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Encephalitis / pathology*
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Granulocytes / immunology
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Granulocytes / microbiology
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Granulocytes / pathology
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Granulocytes / ultrastructure
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HIV / immunology
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HIV / isolation & purification
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HIV Infections / blood
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HIV Infections / immunology
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HIV Infections / pathology*
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HIV-1 / immunology
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HIV-1 / isolation & purification
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Hematopoietic Stem Cells / immunology
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Hematopoietic Stem Cells / microbiology
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Hematopoietic Stem Cells / pathology
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Hematopoietic Stem Cells / ultrastructure
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Humans
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In Vitro Techniques
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Microscopy, Electron
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Monocytes / immunology
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Monocytes / microbiology
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Monocytes / pathology
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Monocytes / ultrastructure