Prediction of gestational hypertension or intrauterine fetal growth restriction by mid-trimester 24-h ambulatory blood pressure monitoring

A L Tranquilli; S R Giannubilo; B Dell'Uomo; A Corradetti

doi:10.1016/j.ijgo.2003.10.003

Prediction of gestational hypertension or intrauterine fetal growth restriction by mid-trimester 24-h ambulatory blood pressure monitoring

Int J Gynaecol Obstet. 2004 May;85(2):126-31. doi: 10.1016/j.ijgo.2003.10.003.

Authors

A L Tranquilli¹, S R Giannubilo, B Dell'Uomo, A Corradetti

Affiliation

¹ Department of Obstetrics and Gynecology, University of Ancona, Ancona, Italy. [email protected]

PMID: 15099773
DOI: 10.1016/j.ijgo.2003.10.003

Abstract

Objectives: To investigate clinical impact of 24-h ambulatory blood pressure monitoring (ABPM) on the prediction of hypertensive disorders of pregnancy and IUGR.

Methods: ABPM was performed in 334 normotensive non-proteinuric nulliparous women at 20 weeks' gestation. Arterial blood pressure patterns were analyzed by chronobiometry.

Results: Women who developed idiopathic IUGR (21) or PIH (33) showed a 24-h diastolic blood pressure mean significantly higher than the controls (69.2+/-1.8 mmHg and 73.5+/-6.2 vs. 62.2+/-1.5). Women with subsequent IUGR also showed a modification in BP rhythm. The most effective cut-off levels of 24-h diastolic blood pressure mean proved to be 67 for IUGR and 68 for hypertension.

Conclusions: ABPM in the second trimester reliably predicts idiopathic IUGR and PIH. Both patients destined to develop gestational hypertension and those destined to develop IUGR show similar elevations in 24-h diastolic mean at 20 weeks' gestation.

MeSH terms

Adult
Blood Pressure / physiology*
Blood Pressure Monitoring, Ambulatory*
Female
Fetal Growth Retardation / diagnosis*
Humans
Hypertension / diagnosis*
Longitudinal Studies
Predictive Value of Tests
Pregnancy
Pregnancy Complications, Cardiovascular / diagnosis*
Pregnancy Trimester, Second / physiology
Sensitivity and Specificity