Abstract
Multidrug resistance proteins (MRPs) have been reported to be involved in the efflux of some anti-human immunodeficiency virus (HIV) drugs. We show here that MRP1, MRP4, and MRP5 are expressed at the mRNA level in human monocyte-derived macrophages. HIV infection caused increased transcription of these MRPs; however, temporal differences in stimulation are reported.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+) / metabolism
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HIV Infections / metabolism*
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Humans
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In Vitro Techniques
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Interleukin-6 / biosynthesis
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Macrophages / metabolism*
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Multidrug Resistance-Associated Proteins / biosynthesis*
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RNA, Messenger / biosynthesis
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Reverse Transcriptase Polymerase Chain Reaction
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Ribosomal Proteins / biosynthesis*
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Tumor Necrosis Factor-alpha / biosynthesis
Substances
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ABCC4 protein, human
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ABCC5 protein, human
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Interleukin-6
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Multidrug Resistance-Associated Proteins
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RNA, Messenger
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Ribosomal Proteins
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Tumor Necrosis Factor-alpha
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Glyceraldehyde 3-Phosphate Dehydrogenase (NADP+)
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multidrug resistance-associated protein 1