Abstract
A series of paclitaxel analogues possessing a macrocyclic structure between the 7 and 10 positions has been prepared. These compounds possess in vitro activity against a paclitaxel resistant cell line and have in vivo activity comparable to paclitaxel.
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology
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Antineoplastic Agents / therapeutic use
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Cell Line, Tumor
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Cell Survival / drug effects
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Drug Resistance, Neoplasm
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Humans
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Inhibitory Concentration 50
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Lung Neoplasms / drug therapy
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Macrocyclic Compounds / chemical synthesis
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Macrocyclic Compounds / pharmacology
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Macrocyclic Compounds / therapeutic use
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Mice
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Neoplasms, Experimental / drug therapy
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Paclitaxel / analogs & derivatives*
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Structure-Activity Relationship
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Taxoids / chemical synthesis*
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Taxoids / pharmacology*
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Taxoids / therapeutic use
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Tubulin Modulators
Substances
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Antineoplastic Agents
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Macrocyclic Compounds
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Taxoids
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Tubulin Modulators
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Paclitaxel