Abstract
Structural modifications were made to a previously described acyl dipeptide caspase inhibitor, leading to the oxamyl dipeptide series. Subsequent SAR studies directed toward the warhead, P2, and P4 regions of this novel peptidomimetic are described herein.
MeSH terms
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Apoptosis / drug effects
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Carbamates
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Caspase Inhibitors*
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Cell Line
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Dipeptides / chemical synthesis*
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Dipeptides / pharmacology*
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Humans
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Inhibitory Concentration 50
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Kinetics
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Neurodegenerative Diseases / drug therapy
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Stroke / drug therapy
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Structure-Activity Relationship
Substances
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Carbamates
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Caspase Inhibitors
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Dipeptides
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oxamyl