Abstract
Two new trachylobane- and one isopimarane-type diterpenoids: ent-18-hydroxy-trachyloban-3-one; ent-trachyloban-3-one; isopimara-7,15-dien-3beta-ol, were isolated from the leaves of Croton zambesicus, together with trans-phytol, beta-sitosterol, alpha-amyrin and stigmasterol. The structures were determined by extensive NMR techniques and X-ray analysis. The cytotoxicity of these compounds has been evaluated on cancer and non-cancer cell-lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Cell Line
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Croton / chemistry*
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Crystallography, X-Ray
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Fibroblasts
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HL-60 Cells
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HeLa Cells
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Leaves / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes