Abstract
Vascular endothelial growth factor (VEGF), basic-fibroblast growth factor (bFGF), hepatocyte growth factor (HGF), and angiogenin are important angiogenic factors. In 65 patients with non-Hodgkin's lymphoma (NHL), pre-treatment VEGF, bFGF, and HGF levels were significantly elevated compared to normal individuals, while angiogenin levels were significantly subnormal. In 37 patients with Hodgkin's disease, pre-treatment levels of VEGF and HGF were significantly elevated, bFGF levels were normal, and angiogenin levels were significantly subnormal. In patients with NHL, post-therapy levels of angiogenin were independently predictive of survival. Both pre-therapy and post-therapy VEGF levels were independently predictive of survival in patients with HD.
MeSH terms
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Female
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Fibroblast Growth Factor 2 / blood
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Hepatocyte Growth Factor / blood
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Hodgkin Disease / blood*
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Hodgkin Disease / pathology
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Hodgkin Disease / therapy
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Humans
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Lymphoma, Follicular / blood
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Lymphoma, Follicular / pathology
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Lymphoma, Follicular / therapy
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Lymphoma, Large B-Cell, Diffuse / blood
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Lymphoma, Large B-Cell, Diffuse / pathology
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Lymphoma, Large B-Cell, Diffuse / therapy
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Lymphoma, Non-Hodgkin / blood*
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Lymphoma, Non-Hodgkin / pathology
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Lymphoma, Non-Hodgkin / therapy
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Male
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Middle Aged
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Neoplastic Cells, Circulating / metabolism*
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Neoplastic Cells, Circulating / pathology
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Neovascularization, Pathologic / blood*
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Predictive Value of Tests
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Ribonuclease, Pancreatic / blood
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Survival Rate
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Vascular Endothelial Growth Factor A / blood
Substances
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Vascular Endothelial Growth Factor A
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Fibroblast Growth Factor 2
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Hepatocyte Growth Factor
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angiogenin
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Ribonuclease, Pancreatic