Dysbindin-1 and schizophrenia: from genetics to neuropathology

J Clin Invest. 2004 May;113(9):1255-7. doi: 10.1172/JCI21470.

Abstract

The gene encoding dysbindin-1 has recently been implicated in susceptibility to schizophrenia. In this issue of the JCI, Talbot et al. show that, contrary to expectations, dysbindin-1 is located presynaptically in glutamatergic neurons and is reduced at these locations in schizophrenia. Further studies of dysbindin-1 and the proteins with which it interacts can be expected to throw light on the pathogenesis of schizophrenia.

Publication types

  • Comment

MeSH terms

  • Brain / metabolism
  • Carrier Proteins / genetics*
  • Carrier Proteins / metabolism
  • Dysbindin
  • Dystrophin-Associated Proteins
  • Genetic Predisposition to Disease
  • Glutamic Acid / metabolism
  • Hippocampus / cytology
  • Hippocampus / metabolism
  • Humans
  • Membrane Transport Proteins*
  • Models, Biological
  • Neurons / metabolism*
  • Neurons / pathology
  • Presynaptic Terminals / metabolism
  • Schizophrenia / etiology
  • Schizophrenia / genetics
  • Schizophrenia / pathology*
  • Tissue Distribution
  • Vesicular Glutamate Transport Protein 1
  • Vesicular Transport Proteins*

Substances

  • Carrier Proteins
  • DTNBP1 protein, human
  • Dysbindin
  • Dystrophin-Associated Proteins
  • Membrane Transport Proteins
  • SLC17A7 protein, human
  • Vesicular Glutamate Transport Protein 1
  • Vesicular Transport Proteins
  • Glutamic Acid